© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

The questions of what represents space-time in GR, the status of gravitational energy, the substantivalist-relationalist issue, and the exceptional status of gravity are interrelated. If space-time has energy-momentum, then space-time is substantival. Two extant ways to avoid the substantivalist conclusion deny that the energy-bearing metric is part of space-time or deny that gravitational energy exists. Feynman linked doubts about gravitational energy to GR-exceptionalism, as do Curiel and Duerr; particle physics egalitarianism encourages realism about gravitational energy. In that spirit, this essay (...) proposes a third possible view about space-time, one involving a particle physics-inspired non-perturbative split that characterizes space-time with a constant background _matrix_, a sort of vacuum value, thus avoiding the inference from gravitational _energy to substantivalism. On this proposal, space-time is, where eta=diag is a spatio-temporally constant numerical signature matrix, a matrix already used in GR with spinors. The gravitational potential, to which any gravitational energy can be ascribed, is g_{\mu\nu}- eta, an _affine_ geometric object with a tensorial Lie derivative and a vanishing covariant derivative. This non-perturbative split permits strong fields, arbitrary coordinates, and arbitrary topology, and hence is pure GR by almost any standard. This razor-thin background, unlike more familiar backgrounds, involves no extra gauge freedom and so lacks their obscurities and carpet lump-moving. After a discussion of Curiel's GR exceptionalist denial of the localizability of gravitational energy and his rejection of energy conservation, the two traditional objections to pseudotensors, coordinate dependence and nonuniqueness, are explored. Both objections are inconclusive and getting weaker. A literal interpretation involving infinitely many energies corresponding by Noether's first theorem to the infinite symmetries of the _action_ largely answers Schroedinger's false-negative coordinate dependence problem. Bauer's false-positive objection has multiple answers. Non-uniqueness might be handled by Nester et al.'s finding physical meaning in multiplicity in relation to boundary conditions, by an optimal candidate, or by Bergmann's identifying the non-uniqueness and coordinate dependence ambiguities as one. (shrink)

The rôle of mathematical models in growth studies is discussed and a distinction made between the structural and descriptive aspects of a mathematical formulation. A simple scheme is set up to represent in broad outline the simultaneous growth and interaction of larval and adult systems inMyrmica rubra and is matched against observed results.

Biotechnology is one of the fastest-growing areas of scientific, technical and industrial innovation and one of the most controversial. As developments have occurred such as genetic test therapies and the breeding of genetically modified food crops, so the public debates have become more heated and grave concerns have been expressed about access to genetic information, labelling of genetically modified foods and human and animal cloning. Across Europe, public opinion has become a crucial factor in the ability of governments and biotech (...) industries to exploit the new technology. This 2002 book presents the results of a unique cross-national and cross-disciplinary study of the relationship between the development of new biotechnology and public perception, media coverage and policy formulation. It outlines a conceptual framework for understanding these issues and contains a number of empirical studies including studies of the international controversies surrounding the cloning of Dolly the sheep and GM Soya. (shrink)

In this work we consider the energy states of muonic atoms which are predominantly influenced by vacuum polarization. This fact is used for testing the electron propagator of QED with the modification $S(p) = (\not p - me)^{ - 1} + f(\not p - M)^{ - 1}$ . The data of some well analyzed transitions in muonic He, Si, Ba, and Pb yield the limit M>29 MeV for f=1.Similarly the presence of a Higgs boson would cause a shift of the (...) energy levels which can be measured easier in muonic atoms since the coupling grows with the fermion mass. The analysis of several transitions in heavy muonic atoms shows, that the mass of the Higgs boson is larger than 12.8 MeV.Further reductions of the present-day uncertainties concerning the experimental data and especially of the nuclear structure effects could improve these limits. (shrink)

BackgroundWith the emergence of Brain Computer Interfaces, clinicians have been facing a new group of patients with severe acquired brain injury who are unable to show any behavioral sign of consciousness but respond to active neuroimaging or electrophysiological paradigms. However, even though well documented, there is still no consensus regarding the nomenclature for this clinical entity.ObjectivesThis systematic review aims to 1) identify the terms used to indicate the presence of this entity through the years, and 2) promote an informed discussion (...) regarding the rationale for these names and the best candidates to name this fascinating disorder.MethodsThe Disorders of Consciousness Special Interest Group of the International Brain Injury Association launched a search on Pubmed and Google scholar following PRISMA guidelines to collect peer-reviewed articles and reviews on human adults published in English between 2006 and 2021.ResultsThe search launched in January 2021 identified 4,089 potentially relevant titles. After screening, 1,126 abstracts were found relevant. Finally, 161 manuscripts were included in our analyses. Only 58% of the manuscripts used a specific name to discuss this clinical entity, among which 32% used several names interchangeably throughout the text. We found 25 different names given to this entity. The five following names were the ones the most frequently used: covert awareness, cognitive motor dissociation, functional locked-in, non-behavioral MCS and higher-order cortex motor dissociation.ConclusionSince 2006, there has been no agreement regarding the taxonomy to use for unresponsive patients who are able to respond to active neuroimaging or electrophysiological paradigms. Developing a standard taxonomy is an important goal for future research studies and clinical translation. We recommend a Delphi study in order to build such a consensus. (shrink)

Since its founding in 1950, the Metaphysical Society of America has remained a pluralistic community dedicated to rigorous philosophical inquiry into the most basic metaphysical questions. At each year’s conference, the presidential address offers original insights into metaphysical questions. Both the insights and the questions are as perennial as they are relevant to contemporary philosophers. This volume collects eighteen of the finest representatives from those presidential addresses, including contributions from George Allan, Richard Bernstein, Norris Clarke, Vincent Colapietro, Frederick Ferré, Jorge (...) J. E. Gracia, Joseph Grange, Marjorie Grene, George Klubertanz, Ivor Leclerc, Ralph McInerny, Ernan McMullin, Joseph Owens, John Herman Randall, Jr., Nicholas Rescher, Stanley Rosen, John E. Smith, and Robert Sokolowski. Also included are Paul Weiss’s inaugural address to the Society, an introduction chronicling the history of the Society, and an original Foreword by William Desmond and Epilogue by Robert Neville. (shrink)

What is the significance of the Protestant Reformation for Christian ethical thinking and action? Can core Protestant commitments and claims still provide for compelling and viable accounts of Christian living. This collection of essays by leading international scholars explores the relevance of the Protestant Reformation and its legacy for contemporary Christian ethics.

In this article the work of a recent critic of moral vegetarianism (and veganism) is analyzed: Andrew F. Smith. Smith s work is significant for process thinkers who defend moral vegetarianism for various reasons. One of these is that he forces process thinkers to consider in more depth Whitehead’s view of plant ontology; another is that Smith adds insightfully to the conversation within process thought regarding the relationship between claims regarding animal rights and the ecoholistic concerns of environmental ethicists.

This book examines from different perspectives the moral significance of non-human members of the biotic community and their omission from climate ethics literature. The complexity of life in an age of rapid climate change demands the development of moral frameworks that recognize and respect the dignity and agency of both human and non-human organisms. Despite decades of careful work in non-anthropocentric approaches to environmental ethics, recent anthologies on climate ethics have largely omitted non-anthropocentric approaches. This multidisciplinary volume of international scholars (...) tackles this lacuna by presenting novel work on non-anthropocentric approaches to climate ethics. Written in an accessible style, the text incorporates sentiocentric, biocentric, and ecocentric perspectives on climate change. With diverse perspectives from both leading and emerging scholars of environmental ethics, geography, religious studies, conservation ecology, and environmental studies, this book will offer a valuable reading for students and scholars of these fields. (shrink)

Legal texts are often given interpretations that deviate from their literal meanings. While legal concerns often motivate these interpretations, others can be traced to linguistic phenomena. This paper argues that systematicities of language usage, captured by certain theories of conversational implicature, can sometimes explain why the meanings given to legal texts by judges differ from the literal meanings of the texts. Paul Grice's account of conversational implicature is controversial, and scholars have offered a variety of ways to conceptualize implicatures and (...) Grice's maxims of conversation. Approaches that emphasize the systematic nature of implicatures can provide explanatory accounts of the gap between literal meaning and the meaning communicated in the text. For example, a theory of scalar implicature, a type of generalized conversational implicature, can account for the application of the interpretive principle known as ejusdem generis, which narrows the scope of “catch-all” clauses located at the end of lists of items. Despite the availability of such theories, some scholars have argued that conversational implicatures are not applicable to legislation. The arguments, based primarily on the uniqueness of the legislative context and its noncooperative nature, though, do not establish the inapplicability of conversational implicatures to legislation. (shrink)

Macroeconomic traditions disagree on the policies needed for the economy to properly function and how to assess them. In this paper, we contend that these disagreements originate from the social ontological commitments of a theory. The ontology of money underlines these disagreements between Modern Monetary Theory (MMT) and mainstream economics. First, we assess MMT’s ontology of money. Next, we identify MMT’s normative commitments and classify MMT’s ontology as a taxonomic definition with thick concepts. Finally, we offer reasons why MMT's ontology (...) of money leads to rivalries with other economic traditions. We argue disagreements on policy are expected, given the ontological differences elaborated. (shrink)

This paper examines the philosophical basis for the argument that there is a connection between ethical behavior and profitability. Both sides of this argument – that good ethics is good business and that bad ethics is bad business – are explored. The possibility of a moral floor above which ethical behavior is not rewarded is considered, and an economic experiment testing such a proposition is discussed. Johnson & Johnson suffers a potentially devastating blow when some cyanide-laced Tylenol capsules cause several (...) deaths. Johnson & Johnson voluntarily pulls Tylenol off the shelf, to universal acclaim. When Tylenol is returned to the marketplace, its share of the over-the-counter painkiller market becomes greater than it was before the tragedy. Arthur Andersen, the venerable accounting firm, is caught in the web surrounding the downfall of Enron, Inc. As Enron’s various sins are discovered, it is found that Arthur Andersen auditors had signed off on flawed audits and had shredded documents to cover themselves. Andersen is prosecuted for, and convicted of, obstructing justice (although the conviction is later overturned). Today the firm barely exists and has no resemblance to the Big Five accounting giant of 1999. These stories seem to indicate that ethical (or unethical) behavior leads to positive (or negative) financial results. But the philosophical arguments underpinning such statements are seldom subjected to proper analysis. They are perhaps wishful thinking, or perhaps based on examples such as the above without considering other examples that may reinforce a contrary position. This paper will explore the philosophical arguments and empirical evidence regarding these statements and state some research questions for exploration in this area. In particular we will propose the possibility that a moral floor exists above which firms that engage in ethical activities will not reap rewards, but below which firms that engage in unethical activities will be punished by actors in the economic marketplace. We will discuss an economic experiment to determine if such actors indeed form a moral floor. (shrink)

The kernel of this chapter has been lodged in my mind since I was a graduate student at Fordham. As I studied the work of Charles Sanders Peirce and Alfred North Whitehead I was continually struck by the numerous points of conver-gence between their respective projects. Unlike other pragmatists, both of these mathematically trained philosophers were interested in constructing a specula-tive philosophy that rejected the reductive, mechanistic accounts of nature. Instead, both Peirce and Whitehead described an emergent, evolutionary cos-mos that (...) was moved by love. Given these and other deep points of conver-gence, I was, and remain, mystified by Whitehead’s nearly complete lack of discussion of his fellow mathematician’s work.1 Here is how I proceed. First I present a brief exposition of the relevant as-pects of Peirce’s and Whitehead’s systems, focusing in particular on their ac-counts of the developmental role of love. Given this backdrop, I then proceed to consider what Peirce and Whitehead might learn from each other. More specifi-cally, considering the metaphysical nature and role of both local and cosmolog-ical forms of teleology in their respective systems, I suggest that certain short-comings in each philosopher’s conception of teleology are at least partially rem-edied by the others. Finally, wanting not merely to think about, but also to think with Peirce and Whitehead, I consider what their conceptions of creative love may have to offer in contemporary debates at the frontiers of evolutionary biology. (shrink)

The opportunity to read and reflect on Presidential Addresses of the American Philosophical Association 1931–1940, the fourth volume of the American Philosophical Association Centennial Series, has been in equal measures rewarding, humbling, and taxing. Having recently completed my own edited volume of presidential addresses of another philosophical society, I have been thoroughly disabused of the notion that there is any particular form or content that defines a philosophical presidential address. Perhaps it should not be surprising that the topics of the (...) addresses are as varied as the field that they represent. Nevertheless, I have endeavored to impose some order on the collection, grouping them into six rough divisions, primarily by their similarity of subject matter or methodology. (shrink)

With the increase of natural disasters, droughts, and superstorms, it’s clear that climate change isn’t coming—it’s here. The ecological crisis of climate change—and how we handle it—is the challenge of this century. Though policy changes or technological advances may help, they’re not enough. We are in need of new ways of thinking and acting; new ways of understanding our relationship to the world. Riders in the Storm assesses the challenges of climate change through an interdisciplinary study, examining the basic scientific, (...) political, economic, and moral dimensions through a framework of philosophical ethics. (shrink)

Considering the role of space and place in Integral Ecology is presented as the concept of Integral Geography. First, an ecological AQAL model is proposed to situate the diverse scientific disciplines used in geography, giving equal consideration for their respective contributions in knowledge and understanding of the world. Second, a model for incorporating perspectives provided in the arts and humanities is proposed in situating scientific understanding in relation to aesthetic and cultural aspects of "being and becoming." Third, a Geographical Information (...) System (GIS) based map model illustrates how biophysical and social realities can be viewed and analyzed from a geographical perspective as "Integral places.". (shrink)

The aim of this essay is twofold. First, I examine the role of Alfred North Whitehead and process thinkers in bringing about and shaping the field of environmental ethics. As we will see, our job is not so much to develop the connections between Whitehead and environmental thought as to recover them. Second, given this genealogical work, I invite process scholars to reconsider their generally hostile reception of Aldo Leopold and his land ethic. I suggest that a version of the (...) land ethic grounded in a process axiology could make a significant contribution to contemporary environmental thought. (shrink)

Argues that, to make progress within environmental ethics, philosophers must explicitly engage in environmental metaphysics.

"Language shapes and reflects how we think about the world. It engages and intrigues us. Our everyday use of language is quite effortless--we are all experts on our native tongues. Despite this, issues of language and meaning have long flummoxed the judges on whom we depend for the interpretation of our most fundamental legal texts. Should a judge feel confident in defining common words in the texts without the aid of a linguist? How is the meaning communicated by the text (...) determined? Should the communicative meaning of texts be decisive, or at least influential?... [Contributors] argue that the meaning of language is crucial to the interpretation of legal texts, such as statutes, constitutions, and contracts. Accordingly... analysis of language from linguists, philosophers, and legal scholars should influence how courts interpret legal texts."--. (shrink)

Objective Our objective was to evaluate whether those individuals with previous involvement with formal clinical ethics processes differ in their attitudes towards the resolution of prototypical clinical ethics cases than general health care professionals. We hypothesized that those individuals with previous participation in ethics consultation would have significantly different attitudes on the appropriate role of ethics committees in the assessment and resolution of clinical ethical dilemmas than those who have not. Methods We conducted a case-based survey of health care professionals (...) at six US hospitals. We administered the survey to health care professionals in a variety of clinical roles at each center and further sub-categorized these by respondents reporting or not reporting their membership on an ethics committee or participation as an ethics consultant/requestor of ethics consult services. Using the analysis of variance test, we present the variation in attitudes using a 5-point Likert scale with 95% confidence intervals and significance set at p ≤ 0.05. Results A total of 240 respondents completed the survey (response rate: 63.6%) from all six surveyed centers (128 respondents with involvement with ethics consultation, 112 respondents without). Health care professionals not previously involved with formal clinical ethics processes were less likely to view the ethics committee as having a role in resolving the presented clinical ethical dilemmas ( p = 0.01 for analysis of variance comparison). Conclusion In this multi-center survey study, health care providers without previous involvement with formal clinical ethics processes were less likely than those with previous involvement to support a role for ethics committees aiding in ethical case resolution. (shrink)

This study aims to describe social network and social participation and to assess associations with depressive symptoms in older persons with increased risk for dementia in Germany. We conducted a cross-sectional observational study in primary care patients (aged 60-77) as part of a multicenter cluster-randomized controlled trial (AgeWell.de). We present descriptive and multivariate analyses for social networks (Lubben Social Network Scale and subscales) and social participation (item list of social activities) and analyze associations of these variables with depressive symptoms (Geriatric (...) Depression Scale). Of 1030 included patients, 17.2% were at risk for social isolation (Lubben Social Network Scale < 12). Looking at the subscales, a reduced non-family network was found almost twice as often as a reduced family network. Patients with depressive symptoms had significantly smaller social networks than patients without depression (p < 0.001). They rather engaged in social activities of low involvement level or no weekly social activity at all (p < 0.001). The study shows associations of depressive symptoms with a decreased social network and less social participation in elderly participants. Sufficient non-family contacts and weekly social activities seem to play an important role in mental health and should be encouraged in elderly primary care patients. (shrink)

Whereas traditional ethical theories limit morality to the relations between human beings, Whitehead seems committed to a fundamentally different model. Yet despite the longstanding consensus among process scholars that Whitehead’s philosophy of organism provides an ideal ground for a rich moral philosophy, particularly one encompassing ecological concerns, there is a relative dearth of scholarship on the topic. What is more, among those who do engage in such scholarship, there seems to be no agreement as to how to classify Whitehead’s ethics, (...) which has at different times been labeled, among other things, a moral interest theory, a totalizing form of utilitarianism, and a virtue ethic.1 Some have even suggested that Whitehead’s metaphysics is consistent with a deontological approach (e.g. Lango 2001). Given the diversity of such conflicting interpretations, one might well wonder whether Whitehead can even be said to have a moral philosophy. In this essay, my primary aim is to bring clarity to the debate over Whitehead’s ethics by systematically examining Whitehead’s own scattered remarks on morality. I will demonstrate that, although he may not have systematically elaborated a complete moral philosophy, he did indeed affirm a model of morality that is every bit as unique, fallible, and speculative as his metaphysics. (shrink)

It has been said that new discoveries and developments in the human, social, and natural sciences hang “in the air” (Bowler, 1983; 2008) prior to their consummation. While neo-Darwinist biology has been powerfully served by its mechanistic metaphysic and a reductionist methodology in which living organisms are considered machines, many of the chapters in this volume place this paradigm into question. Pairing scientists and philosophers together, this volume explores what might be termed “the New Frontiers” of biology, namely contemporary areas (...) of research that appear to call an updating, a supplementation, or a relaxation of some of the main tenets of the Modern Synthesis. Such areas of investigation include: Emergence Theory, Systems Biology, Biosemiotics, Homeostasis, Symbiogenesis, Niche Construction, the Theory of Organic Selection (also known as “the Baldwin Effect”), Self-Organization and Teleodynamics, as well as Epigenetics. Most of the chapters in this book offer critical reflections on the neo-Darwinist outlook and work to promote a novel synthesis that is open to a greater degree of inclusivity as well as to a more holistic orientation in the biological sciences. (shrink)

My goal in this brief essay is not so much to defend White's controversial thesis, but to use it as a context for appreciating the significance of Pope Francis's new encyclical Laudato Si’. Considering it in the context of White’s thesis, will bring certain salient features into relief.

While most scholars readily recognize that Alfred North Whitehead had deep and penetrating misgivings about the substantial view of individuality, fewer note that these misgivings stem as much from axiological considerations as ontological ones. I contend that, taken in the context of the “classical interpretation” of his metaphysics, Whitehead’s bold affirmation that actuality and value are coextensive introduces a potentially serious problem for the adequacy and applicability of his axiology. For if actuality is coextensive with valuebut actuality is itself limited (...) to subjects of experience, then the objective world can have no intrinsic value. My aim is to demonstrate that, in order to respond to the very serious challenge which the problem of subjectivism represents and save Whitehead’s intendeduniverse of value, we must seek an alternative to the classical interpretation of Whitehead’s metaphysics. I refer to this alternative as the “ecstatic interpretation.”. (shrink)

Process philosophy has traditionally focused predominantly on ontology and cosmology. However, in the closing decades of the twentieth century, the scope of its application broadened significantly to include areas such as theology, physics, biology, psychology, and even education. But, one area that was not so fortunate is ethics. Process philosophy, nonetheless, has the potential to make a unique contribution to the state of ethical theory, which, having the support of a process ontology, could avoid many of the pitfalls which plague (...) modern ethical theories. Nowhere are these pitfalls more apparent than in the philosophy of Immanuel Kant, to whom I am alluding in the title of this paper. For, in keeping with his metaphysics, Kant made the absolute value of the autonomous rational individual the supreme principle of morality and, in so doing, made the human in particular, and ethics in general, discontinuous with the goings-on of the rest of the universe.1 In stark contrast to this longstanding tradition, it is my intention to demonstrate that it is possible to construct an axiological ethical system which makes humans an exemplification of the aim of the universe rather than an exception to it. My argument proceeds in roughly four parts. I begin by outlining the basic contours of Whitehead’s metaphysics and aesthetics and the relation between them. With this as a backdrop, I then proceed to discuss the moral dimension of Whitehead’s thought and the standard objections to it. In the third section, I respond to these objections, first, by contrasting two different interpretations of Whitehead’s metaphysics and, then, by examining the forms of morality that each entails. Finally, I conclude with my own speculations on how one might proceed to develop a systematic moral philosophy based on a Whiteheadian aesthetics of process. (shrink)